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Under cancer conditions, hypoxic levels in the cellular microenvironment inhibited the normal physiological processes, leading to stable accumulation of HIF-1α and HIF-2α ( HIF-1α and HIF-1β are primary oxygen-limiting sensors and their induction support cancer cell proliferation during hypoxia and diverse metabolic alterations

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Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model